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Summary of preclinical and clinical inhibitors that target MDSC development, suppressive activity, and differentiation
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Summary of preclinical and clinical inhibitors that target MDSC development, suppressive activity, and differentiation
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Summary of preclinical and clinical inhibitors that target MDSC development, suppressive activity, and differentiation

Journal: Journal of Leukocyte Biology

Article Title: Myeloid‐derived suppressor cells—a new therapeutic target to overcome resistance to cancer immunotherapy

doi: 10.1189/jlb.5VMR1116-458RRR

Figure Lengend Snippet: Summary of preclinical and clinical inhibitors that target MDSC development, suppressive activity, and differentiation

Article Snippet: Oligodeoxynucleotides CpG ODN and drugs such as nitroaspirin (NicOx, Valbonne, France) and N ‐acetyl cysteine modulate ARG1 and iNOS production, which are the central mediators of MDSC suppressive activity [ 119 , 120 – 121 ]. dODNs, which comprise STAT3‐specific DNA sequences are competitive inhibitors of STAT3 transcriptional activity [ 122 ].

Techniques: Activity Assay, Inhibition, Modification, Expressing, Activation Assay